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Do side effects of methotrexate go away? Methotrexate users may develop other issues, but many can be monitored by regular blood tests. These side effects often go away if you stop taking the drug temporarily (which should only be done under a doctor's supervision).
Why is methotrexate not working? Treatment with methotrexate alone isn't working well enough. This is the most common reason for taking biologics. Your doctor will regularly examine your joints and test your blood for signs of RA. If methotrexate isn't helping enough, he or she might add a biologic.
Can methotrexate cause bladder problems? Methotrexate elimination is reduced in patients with impaired renal function, ascites, or pleural effusions. Increased risk of soft tissue necrosis and osteonecrosis with concomitant radiotherapy. Malignant lymphoma may occur. Along with its needed effects, methotrexate may cause some unwanted effects.
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